Cargando…

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

Here we analyzed the function of the c-MYC-inducible basic helix–loop–helix leucine-zipper transcription factor AP4 in AP4-deficient mouse embryo fibroblasts (MEFs). Loss of AP4 resulted in premature senescence and resistance towards immortalization. Senescence was accompanied by induction of the cy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jackstadt, R, Jung, P, Hermeking, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763444/ https://www.ncbi.nlm.nih.gov/pubmed/23949224 http://dx.doi.org/10.1038/cddis.2013.282

Ejemplares similares

AP4 is required for mitogen- and c-MYC-induced cell cycle progression
por: Jackstadt, Rene, et al.
Publicado: (2014)

c-MYC-Induced AP4 Attenuates DREAM-Mediated Repression by p53
por: Kaller, Markus, et al.
Publicado: (2023)

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer
por: Jackstadt, Rene, et al.
Publicado: (2013)

AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p
por: Chou, Jinjiang, et al.
Publicado: (2022)

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
por: Siemens, Helge, et al.
Publicado: (2013)

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells
por: Jaeckel, Stephanie, et al.
Publicado: (2018)

Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways
por: Tang, Hailong, et al.
Publicado: (2018)

Suppression of p16 alleviates the senescence-associated secretory phenotype
por: Buj, Raquel, et al.
Publicado: (2021)

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
por: Wagner, Kay-Dietrich, et al.
Publicado: (2022)

TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling
por: Hou, Zhenlin, et al.
Publicado: (2018)

p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3
por: Hünten, Sabine, et al.
Publicado: (2015)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

Cooperative p16 and p21 action protects female astrocytes from transformation
por: Kfoury, Najla, et al.
Publicado: (2018)

Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice
por: Lee, Su-Jeong, et al.
Publicado: (2022)

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21
por: Cosi, Irene, et al.
Publicado: (2020)

Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die
por: Wong, Matthew Man-Kin, et al.
Publicado: (2021)

Nanog induces suppression of senescence through downregulation of p27(KIP1) expression
por: Münst, Bernhard, et al.
Publicado: (2016)

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16(INK4a) inactivation
por: Li, Xiangrui, et al.
Publicado: (2018)

IκB kinase β Mediating the Downregulation of p53 and p21 by Lipopolysaccharide in Human Papillomavirus 16(+) Cervical Cancer Cells
por: Tan, Zhi-Hui, et al.
Publicado: (2016)

Cellular senescence mediated by p16(INK4A)-coupled miRNA pathways
por: Overhoff, Marita G., et al.
Publicado: (2014)

p21 and p27 a shared senescence history
por: Flores, Juana María, et al.
Publicado: (2014)

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion
por: Leontieva, Olga V, et al.
Publicado: (2013)

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis
por: Ou, Kepeng, et al.
Publicado: (2022)

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
por: Chandra, Abhishek, et al.
Publicado: (2022)

MZF1 mediates oncogene-induced senescence by promoting the transcription of p16(INK4A)
por: Wu, Dan, et al.
Publicado: (2022)

Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells
por: Lin, Shu, et al.
Publicado: (2012)

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc
por: Gao, Feng-Hou, et al.
Publicado: (2010)

TGF-β1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction
por: Ueda, Sayo, et al.
Publicado: (2021)

P16INK4A—More Than a Senescence Marker
por: Safwan-Zaiter, Hasan, et al.
Publicado: (2022)

Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer
por: Jung, DeokBeom, et al.
Publicado: (2018)

OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases
por: Lu, Yan, et al.
Publicado: (2019)

Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
por: Mirzayans, Razmik, et al.
Publicado: (2012)

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21
por: da Silva, Aline, et al.
Publicado: (2020)

p21-Activated Kinase 3 (PAK3) Is an AP-1 Regulated Gene Contributing to Actin Organisation and Migration of Transformed Fibroblasts
por: Holderness Parker, Nina, et al.
Publicado: (2013)

p16(INK4a)-induced senescence is disabled by melanoma-associated mutations
por: Haferkamp, Sebastian, et al.
Publicado: (2008)

Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
por: Kim, Young Yeon, et al.
Publicado: (2017)

Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model
por: Yuan, Haixin, et al.
Publicado: (2017)

p16(INK4A) Positively Regulates p21(WAF1) Expression by suppressing AUF1-dependent mRNA decay
por: Al-Khalaf, Huda H., et al.
Publicado: (2013)

Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells
por: Niu, Jing, et al.
Publicado: (2021)

Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs
por: Kim, Hyun-Woo, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i9fg2jvmsq0uepp9s9q2hn99sf