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AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation

Here we analyzed the function of the c-MYC-inducible basic helix–loop–helix leucine-zipper transcription factor AP4 in AP4-deficient mouse embryo fibroblasts (MEFs). Loss of AP4 resulted in premature senescence and resistance towards immortalization. Senescence was accompanied by induction of the cy...

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Detalles Bibliográficos
Autores principales:	Jackstadt, R, Jung, P, Hermeking, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763444/ https://www.ncbi.nlm.nih.gov/pubmed/23949224 http://dx.doi.org/10.1038/cddis.2013.282

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