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Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells

Oxidized bases in DNA have been implicated in cancer, aging and neurodegenerative disease. We have developed an approach combining single-cell gel electrophoresis (comet) with fluorescence in situ hybridization (FISH) that enables the comparative quantification of low, physiologically relevant level...

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Detalles Bibliográficos
Autores principales:	Guo, Jia, Hanawalt, Philip C., Spivak, Graciela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763531/ https://www.ncbi.nlm.nih.gov/pubmed/23775797 http://dx.doi.org/10.1093/nar/gkt524

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