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Carcinogenic adducts induce distinct DNA polymerase binding orientations

DNA polymerases must accurately replicate DNA to maintain genome integrity. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), covalently bind DNA bases and promote mutagenesis near the adduct site. The mechanism by which carcinogenic adducts inhibit DNA synthesis...

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Detalles Bibliográficos
Autores principales:	Vrtis, Kyle B., Markiewicz, Radoslaw P., Romano, Louis J., Rueda, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763543/ https://www.ncbi.nlm.nih.gov/pubmed/23814187 http://dx.doi.org/10.1093/nar/gkt554

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