Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

HIV-infected individuals currently cannot be completely cured because existing antiviral therapy regimens do not address HIV provirus DNA, flanked by long terminal repeats (LTRs), already integrated into host genome. Here, we present a possible alternative therapeutic approach to specifically and di...

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Detalles Bibliográficos
Autores principales: Qu, Xiying, Wang, Pengfei, Ding, Donglin, Li, Lin, Wang, Haibo, Ma, Li, Zhou, Xin, Liu, Shaohui, Lin, Shiguan, Wang, Xiaohui, Zhang, Gongmin, Liu, Sijie, Liu, Lin, Wang, Jianhua, Zhang, Feng, Lu, Daru, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763554/
https://www.ncbi.nlm.nih.gov/pubmed/23804764
http://dx.doi.org/10.1093/nar/gkt571

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