Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA

Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phas...

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Detalles Bibliográficos
Autores principales: Arima, Hidetoshi, Motoyama, Keiichi, Higashi, Taishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763628/
https://www.ncbi.nlm.nih.gov/pubmed/24288043
http://dx.doi.org/10.3390/ph5010061
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author Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
author_facet Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
author_sort Arima, Hidetoshi
collection PubMed
description Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system.
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spelling pubmed-37636282013-11-14 Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA Arima, Hidetoshi Motoyama, Keiichi Higashi, Taishi Pharmaceuticals (Basel) Review Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range of biomedical applications, including the interaction and intracellular delivery of DNA and RNA. The present review will address the latest developments in dendrimer conjugates with cyclodextrins for siRNA delivery including the novel sustained release system. MDPI 2011-12-30 /pmc/articles/PMC3763628/ /pubmed/24288043 http://dx.doi.org/10.3390/ph5010061 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title_full Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title_fullStr Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title_full_unstemmed Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title_short Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
title_sort potential use of polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for sirna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763628/
https://www.ncbi.nlm.nih.gov/pubmed/24288043
http://dx.doi.org/10.3390/ph5010061
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AT higashitaishi potentialuseofpolyamidoaminedendrimerconjugateswithcyclodextrinsasnovelcarriersforsirna

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