The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity

Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, (1)H- and (...

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Autores principales: Hasan, Noviany, Osman, Hasnah, Mohamad, Suriyati, Wong, Keng Chong, Awang, Khalijah, Zahariluddin, Anis Safirah Mohd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763669/
https://www.ncbi.nlm.nih.gov/pubmed/24280680
http://dx.doi.org/10.3390/ph5080882
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author Hasan, Noviany
Osman, Hasnah
Mohamad, Suriyati
Wong, Keng Chong
Awang, Khalijah
Zahariluddin, Anis Safirah Mohd
author_facet Hasan, Noviany
Osman, Hasnah
Mohamad, Suriyati
Wong, Keng Chong
Awang, Khalijah
Zahariluddin, Anis Safirah Mohd
author_sort Hasan, Noviany
collection PubMed
description Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, (1)H- and (13)C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1–3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.
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spelling pubmed-37636692013-11-14 The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity Hasan, Noviany Osman, Hasnah Mohamad, Suriyati Wong, Keng Chong Awang, Khalijah Zahariluddin, Anis Safirah Mohd Pharmaceuticals (Basel) Article Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, (1)H- and (13)C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL for compounds 1–3, and 100 µg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 µg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity. MDPI 2012-08-23 /pmc/articles/PMC3763669/ /pubmed/24280680 http://dx.doi.org/10.3390/ph5080882 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hasan, Noviany
Osman, Hasnah
Mohamad, Suriyati
Wong, Keng Chong
Awang, Khalijah
Zahariluddin, Anis Safirah Mohd
The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title_full The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title_fullStr The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title_full_unstemmed The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title_short The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity
title_sort chemical components of sesbania grandiflora root and their antituberculosis activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763669/
https://www.ncbi.nlm.nih.gov/pubmed/24280680
http://dx.doi.org/10.3390/ph5080882
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