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Genetics in Diabetic Retinopathy: Current Concepts and New Insights
There is emerging evidence which indicates the essential role of genetic factors in the development of diabetic retinopathy (DR). In this regard it should be highlighted that genetic factors account for 25-50% of the risk of developing DR. Therefore, the use of genetic analysis to identify those dia...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763680/ https://www.ncbi.nlm.nih.gov/pubmed/24403848 http://dx.doi.org/10.2174/13892029113149990008 |
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author | Simó-Servat, Olga Hernández, Cristina Simó, Rafael |
author_facet | Simó-Servat, Olga Hernández, Cristina Simó, Rafael |
author_sort | Simó-Servat, Olga |
collection | PubMed |
description | There is emerging evidence which indicates the essential role of genetic factors in the development of diabetic retinopathy (DR). In this regard it should be highlighted that genetic factors account for 25-50% of the risk of developing DR. Therefore, the use of genetic analysis to identify those diabetic patients most prone to developing DR might be useful in designing a more individualized treatment. In this regard, there are three main research strategies: candidate gene studies, linkage studies and Genome-Wide Association Studies (GWAS). In the candidate gene approach, several genes encoding proteins closely related to DR development have been analyzed. The linkage studies analyze shared alleles among family members with DR under the assumption that these predispose to a more aggressive development of DR. Finally, Genome-Wide Association Studies (GWAS) are a new tool involving a massive evaluation of single nucleotide polymorphisms (SNP) in large samples. In this review the available information using these three methodologies is critically analyzed. A genetic approach in order to identify new candidates in the pathogenesis of DR would permit us to design more targeted therapeutic strategies in order to decrease this devastating complication of diabetes. Basic researchers, ophthalmologists, diabetologists and geneticists should work together in order to gain new insights into this issue. |
format | Online Article Text |
id | pubmed-3763680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-37636802014-02-01 Genetics in Diabetic Retinopathy: Current Concepts and New Insights Simó-Servat, Olga Hernández, Cristina Simó, Rafael Curr Genomics Article There is emerging evidence which indicates the essential role of genetic factors in the development of diabetic retinopathy (DR). In this regard it should be highlighted that genetic factors account for 25-50% of the risk of developing DR. Therefore, the use of genetic analysis to identify those diabetic patients most prone to developing DR might be useful in designing a more individualized treatment. In this regard, there are three main research strategies: candidate gene studies, linkage studies and Genome-Wide Association Studies (GWAS). In the candidate gene approach, several genes encoding proteins closely related to DR development have been analyzed. The linkage studies analyze shared alleles among family members with DR under the assumption that these predispose to a more aggressive development of DR. Finally, Genome-Wide Association Studies (GWAS) are a new tool involving a massive evaluation of single nucleotide polymorphisms (SNP) in large samples. In this review the available information using these three methodologies is critically analyzed. A genetic approach in order to identify new candidates in the pathogenesis of DR would permit us to design more targeted therapeutic strategies in order to decrease this devastating complication of diabetes. Basic researchers, ophthalmologists, diabetologists and geneticists should work together in order to gain new insights into this issue. Bentham Science Publishers 2013-08 2013-08 /pmc/articles/PMC3763680/ /pubmed/24403848 http://dx.doi.org/10.2174/13892029113149990008 Text en ©2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Simó-Servat, Olga Hernández, Cristina Simó, Rafael Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title | Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title_full | Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title_fullStr | Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title_full_unstemmed | Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title_short | Genetics in Diabetic Retinopathy: Current Concepts and New Insights |
title_sort | genetics in diabetic retinopathy: current concepts and new insights |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763680/ https://www.ncbi.nlm.nih.gov/pubmed/24403848 http://dx.doi.org/10.2174/13892029113149990008 |
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