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Simulations of Biased Agonists in the β(2) Adrenergic Receptor with Accelerated Molecular Dynamics

[Image: see text] The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G protein-signaling pathway a GPCR promotes intracellular signals though β-arrestin, is a novel paradigm in pharmacology. Biochemical and biophysical studies have suggested that a GPCR...

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Detalles Bibliográficos
Autores principales:	Tikhonova, Irina G., Selvam, Balaji, Ivetac, Anthony, Wereszczynski, Jeff, McCammon, J. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763781/ https://www.ncbi.nlm.nih.gov/pubmed/23879802 http://dx.doi.org/10.1021/bi400499n

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