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Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

In this communication we describe a novel acid-cleavable linker strategy for antibody–drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody–drug conjugate bearing a thiomaleamic acid linker. This linker is...

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Detalles Bibliográficos
Autores principales:	Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2013
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763782/ https://www.ncbi.nlm.nih.gov/pubmed/23929130 http://dx.doi.org/10.1039/c3cc45220d

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