PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells

BACKGROUND: PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted...

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Detalles Bibliográficos
Autores principales: Smida, Michal, Cammann, Clemens, Gurbiel, Slavyana, Kerstin, Nadja, Lingel, Holger, Lindquist, Sabine, Simeoni, Luca, Brunner-Weinzierl, Monika C, Suchanek, Miloslav, Schraven, Burkhart, Lindquist, Jonathan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763844/
https://www.ncbi.nlm.nih.gov/pubmed/23601194
http://dx.doi.org/10.1186/1478-811X-11-28

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