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High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon

BACKGROUND: In an earlier study, we detected an association between human T-cell lymphotropic virus (HTLV) infection and cervical human papillomavirus (HPV) in indigenous Amazonian Peruvian women of the Shipibo-Konibo ethnic group. As both HTLV and HPV can be transmitted sexually, we now report a po...

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Autores principales: Blas, Magaly M., Alva, Isaac E., García, Patricia J., Cárcamo, Cesar, Montano, Silvia M., Mori, Nicanor, Muñante, Ricardo, Zunt, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763997/
https://www.ncbi.nlm.nih.gov/pubmed/24040133
http://dx.doi.org/10.1371/journal.pone.0073978
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author Blas, Magaly M.
Alva, Isaac E.
García, Patricia J.
Cárcamo, Cesar
Montano, Silvia M.
Mori, Nicanor
Muñante, Ricardo
Zunt, Joseph R.
author_facet Blas, Magaly M.
Alva, Isaac E.
García, Patricia J.
Cárcamo, Cesar
Montano, Silvia M.
Mori, Nicanor
Muñante, Ricardo
Zunt, Joseph R.
author_sort Blas, Magaly M.
collection PubMed
description BACKGROUND: In an earlier study, we detected an association between human T-cell lymphotropic virus (HTLV) infection and cervical human papillomavirus (HPV) in indigenous Amazonian Peruvian women of the Shipibo-Konibo ethnic group. As both HTLV and HPV can be transmitted sexually, we now report a population-based study examining the prevalence and risk factors for HTLV-1 and HTLV-2 infection in this population. METHODS: Between July and December 2010, we conducted a comprehensive screening for HTLV among Shipibo-Konibo women 15 to 39 years of age living in two communities located in Lima and in 17 communities located within four hours by car or boat from the Amazonian city of Pucallpa in Peru. RESULTS: We screened 1,253 Shipibo-Konibo women for HTLV infection 74 (5.9%) tested positive for HTLV-1, 47 (3.8%) for HTLV-2 infection, and 4 (0.3%) had indeterminate results. In the multivariate analysis, factors associated with HTLV-1 infection included: older age (Prevalence Ratio (PR): 1.04, 95% CI 1.00–1.08), primary education or less (PR: 2.01, 95% CI: 1.25–3.24), younger or same age most recent sex partner (PR: 1.66, 95% CI: 1.00–2.74), and having a most recent sex partner who worked at a logging camp (PR: 1.73, 95% CI: 1.09–2.75). The only factor associated with HTLV-2 infection was older age (PR: 1.08, 95% CI: 1.03–1.12). CONCLUSION: HTLV infection is endemic among Shipibo-Konibo women. Two characteristics of the sexual partner (younger age and labor history) were associated with infection in women. These results suggest the need for implementation of both HTLV screening during the antenatal healthcare visits of Shipibo-Konibo women, and counseling about the risk of HTLV transmission through prolonged breastfeeding in infected women. We also recommend the implementation of prevention programs to reduce sexual transmission of these viruses.
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spelling pubmed-37639972013-09-13 High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon Blas, Magaly M. Alva, Isaac E. García, Patricia J. Cárcamo, Cesar Montano, Silvia M. Mori, Nicanor Muñante, Ricardo Zunt, Joseph R. PLoS One Research Article BACKGROUND: In an earlier study, we detected an association between human T-cell lymphotropic virus (HTLV) infection and cervical human papillomavirus (HPV) in indigenous Amazonian Peruvian women of the Shipibo-Konibo ethnic group. As both HTLV and HPV can be transmitted sexually, we now report a population-based study examining the prevalence and risk factors for HTLV-1 and HTLV-2 infection in this population. METHODS: Between July and December 2010, we conducted a comprehensive screening for HTLV among Shipibo-Konibo women 15 to 39 years of age living in two communities located in Lima and in 17 communities located within four hours by car or boat from the Amazonian city of Pucallpa in Peru. RESULTS: We screened 1,253 Shipibo-Konibo women for HTLV infection 74 (5.9%) tested positive for HTLV-1, 47 (3.8%) for HTLV-2 infection, and 4 (0.3%) had indeterminate results. In the multivariate analysis, factors associated with HTLV-1 infection included: older age (Prevalence Ratio (PR): 1.04, 95% CI 1.00–1.08), primary education or less (PR: 2.01, 95% CI: 1.25–3.24), younger or same age most recent sex partner (PR: 1.66, 95% CI: 1.00–2.74), and having a most recent sex partner who worked at a logging camp (PR: 1.73, 95% CI: 1.09–2.75). The only factor associated with HTLV-2 infection was older age (PR: 1.08, 95% CI: 1.03–1.12). CONCLUSION: HTLV infection is endemic among Shipibo-Konibo women. Two characteristics of the sexual partner (younger age and labor history) were associated with infection in women. These results suggest the need for implementation of both HTLV screening during the antenatal healthcare visits of Shipibo-Konibo women, and counseling about the risk of HTLV transmission through prolonged breastfeeding in infected women. We also recommend the implementation of prevention programs to reduce sexual transmission of these viruses. Public Library of Science 2013-09-05 /pmc/articles/PMC3763997/ /pubmed/24040133 http://dx.doi.org/10.1371/journal.pone.0073978 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Blas, Magaly M.
Alva, Isaac E.
García, Patricia J.
Cárcamo, Cesar
Montano, Silvia M.
Mori, Nicanor
Muñante, Ricardo
Zunt, Joseph R.
High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title_full High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title_fullStr High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title_full_unstemmed High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title_short High Prevalence of Human T-Lymphotropic Virus Infection in Indigenous Women from the Peruvian Amazon
title_sort high prevalence of human t-lymphotropic virus infection in indigenous women from the peruvian amazon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763997/
https://www.ncbi.nlm.nih.gov/pubmed/24040133
http://dx.doi.org/10.1371/journal.pone.0073978
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