Characterizing Changes in the Rate of Protein-Protein Dissociation upon Interface Mutation Using Hotspot Energy and Organization

Predicting the effects of mutations on the kinetic rate constants of protein-protein interactions is central to both the modeling of complex diseases and the design of effective peptide drug inhibitors. However, while most studies have concentrated on the determination of association rate constants,...

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Detalles Bibliográficos
Autores principales: Agius, Rudi, Torchala, Mieczyslaw, Moal, Iain H., Fernández-Recio, Juan, Bates, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764008/
https://www.ncbi.nlm.nih.gov/pubmed/24039569
http://dx.doi.org/10.1371/journal.pcbi.1003216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764008/
https://www.ncbi.nlm.nih.gov/pubmed/24039569
http://dx.doi.org/10.1371/journal.pcbi.1003216

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