Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication

The type III receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3) is expressed on both normal hematopoietic stem cells and acute myeloid leukemia (AML) cells and regulates their proliferation. Internal tandem duplication (ITD) mutation of FLT3 is present in a third of AML cases, results in con...

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Detalles Bibliográficos
Autores principales: Natarajan, Karthika, Xie, Yingqiu, Burcu, Mehmet, Linn, Douglas E., Qiu, Yun, Baer, Maria R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764066/
https://www.ncbi.nlm.nih.gov/pubmed/24040307
http://dx.doi.org/10.1371/journal.pone.0074653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764066/
https://www.ncbi.nlm.nih.gov/pubmed/24040307
http://dx.doi.org/10.1371/journal.pone.0074653

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