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Cdk5 Inhibitory Peptide (CIP) Inhibits Cdk5/p25 Activity Induced by High Glucose in Pancreatic Beta Cells and Recovers Insulin Secretion from p25 Damage

Cdk5/p25 hyperactivity has been demonstrated to lead to neuron apoptosis and degenerations. Chronic exposure to high glucose (HG) results in hyperactivity of Cdk5 and reduced insulin secretion. Here, we set out to determine whether abnormal upregulation of Cdk5/p25 activity may be induced in a pancr...

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Detalles Bibliográficos
Autores principales:	Zheng, Ya-Li, Li, Congyu, Hu, Ya-Fang, Cao, Li, Wang, Hui, Li, Bo, Lu, Xiao-Hua, Bao, Li, Luo, Hong-Yan, Shukla, Varsha, Amin, Niranjana D., Pant, Harish C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764143/ https://www.ncbi.nlm.nih.gov/pubmed/24039692 http://dx.doi.org/10.1371/journal.pone.0063332

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