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Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts a...

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Detalles Bibliográficos
Autores principales:	Westra, Edze R., Semenova, Ekaterina, Datsenko, Kirill A., Jackson, Ryan N., Wiedenheft, Blake, Severinov, Konstantin, Brouns, Stan J. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764190/ https://www.ncbi.nlm.nih.gov/pubmed/24039596 http://dx.doi.org/10.1371/journal.pgen.1003742

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