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Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model

There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders, including Spinocerebellar Ataxia Type-3 (SCA3). Here, we augment the proteostasis network of Drosophila SCA3 models with Hsp104, a powerful protein disaggregase...

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Detalles Bibliográficos
Autores principales:	Cushman-Nick, Mimi, Bonini, Nancy M., Shorter, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764203/ https://www.ncbi.nlm.nih.gov/pubmed/24039611 http://dx.doi.org/10.1371/journal.pgen.1003781

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