Experimentally Validated Novel Inhibitors of Helicobacter pylori Phosphopantetheine Adenylyltransferase Discovered by Virtual High-Throughput Screening

Helicobacter pylori is a major etiologic agent associated with the development and maintenance of human gastritis. The goal of this study was to develop novel antibiotics against H. pylori, and we thus targeted H. pylori phosphopantetheine adenylyltransferase (HpPPAT). PPAT catalyzes the penultimate...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Chao-Sheng, Jia, Kai-Fan, Chen, Ting, Chang, Shun-Ya, Lin, Ming-Shen, Yin, Hsien-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764209/
https://www.ncbi.nlm.nih.gov/pubmed/24040220
http://dx.doi.org/10.1371/journal.pone.0074271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764209/
https://www.ncbi.nlm.nih.gov/pubmed/24040220
http://dx.doi.org/10.1371/journal.pone.0074271

Ejemplares similares