Cargando…

Experimentally Validated Novel Inhibitors of Helicobacter pylori Phosphopantetheine Adenylyltransferase Discovered by Virtual High-Throughput Screening

Helicobacter pylori is a major etiologic agent associated with the development and maintenance of human gastritis. The goal of this study was to develop novel antibiotics against H. pylori, and we thus targeted H. pylori phosphopantetheine adenylyltransferase (HpPPAT). PPAT catalyzes the penultimate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Chao-Sheng, Jia, Kai-Fan, Chen, Ting, Chang, Shun-Ya, Lin, Ming-Shen, Yin, Hsien-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764209/ https://www.ncbi.nlm.nih.gov/pubmed/24040220 http://dx.doi.org/10.1371/journal.pone.0074271

Ejemplares similares

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei
por: Edwards, Thomas E., et al.
Publicado: (2011)

Probing the Phosphopantetheine Arm Conformations of Acyl Carrier Proteins Using Vibrational Spectroscopy
por: Johnson, Matthew N. R., et al.
Publicado: (2014)

Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi
por: Niño, Carlos H, et al.
Publicado: (2015)

A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD
por: Camara, Ali, et al.
Publicado: (2020)

Correction to “Probing the Phosphopantetheine Arm Conformations of Acyl Carrier Proteins Using Vibrational Spectroscopy”
por: Johnson, Matthew N. R., et al.
Publicado: (2014)

Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
por: Di Meo, Ivano, et al.
Publicado: (2017)

4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN
por: Jeong, Suh Young, et al.
Publicado: (2019)

A Newly Discovered Drug Resistance Gene rfaF In Helicobacter pylori
por: Lin, Jiansheng, et al.
Publicado: (2019)

Characteristics and Early Diagnosis of Gastric Cancer Discovered after Helicobacter pylori Eradication
por: Ito, Masanori, et al.
Publicado: (2021)

4′-phosphopantetheine acts as a potential antioxidant to limit atherosclerotic plaque formation by inhibiting ROS generation
por: Zhai, Taiyu, et al.
Publicado: (2022)

Analysis of by high-throughput sequencing: Helicobacter pylori infection and salivary microbiome
por: Ji, Yingjie, et al.
Publicado: (2020)

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design
por: Thomas, Sherine E., et al.
Publicado: (2022)

Catechins and Sialic Acid Attenuate Helicobacter pylori-Triggered Epithelial Caspase-1 Activity and Eradicate Helicobacter pylori Infection
por: Yang, Jyh-Chin, et al.
Publicado: (2013)

Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro
por: Stancek, Martin, et al.
Publicado: (2005)

Adenylylsulfate–ammonia adenylyltransferase activity is another inherent property of Fhit proteins
por: Wojdyła-Mamoń, Anna M., et al.
Publicado: (2015)

Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly
por: Contreras-Rodríguez, Luis Ernesto, et al.
Publicado: (2018)

Protein-protein interactions of the nicotinamide/nicotinate mononucleotide adenylyltransferase of Leishmania braziliensis
por: Ortiz-Joya, Lesly, et al.
Publicado: (2019)

Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase
por: Contreras Rodríguez, Luis Ernesto, et al.
Publicado: (2020)

Validation of a High-Throughput Multiplex Genetic Detection System for Helicobacter pylori Identification, Quantification, Virulence, and Resistance Analysis
por: Zhang, Yanmei, et al.
Publicado: (2016)

Helicobacter pylori
por: Harris, A. W. (Adam W.), 1963-
Publicado: (1996)

Helicobacter Pylori
por: Aguilar Lasserre, Rubén
Publicado: (1998)

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection
por: Ho, Cheng-Yu, et al.
Publicado: (2022)

Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold
por: Goepfert, Arnaud, et al.
Publicado: (2013)

Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia
por: Cox, Georgina, et al.
Publicado: (2015)

Identification of a nicotinamide/nicotinate mononucleotide adenylyltransferase in Giardia lamblia (GlNMNAT)
por: Forero-Baena, Nicolás, et al.
Publicado: (2015)

ERRATUM: Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly”
Publicado: (2018)

The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins
por: Huang, Chengan, et al.
Publicado: (2022)

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
por: Olubiyi, Olujide O., et al.
Publicado: (2020)

Elevated Interleukin-32 Expression Is Associated with Helicobacter pylori-Related Gastritis
por: Peng, Liu-sheng, et al.
Publicado: (2014)

Evodiamine Inhibits Helicobacter pylori Growth and Helicobacter pylori-Induced Inflammation
por: Yang, Ji Yeong, et al.
Publicado: (2021)

Absence of vertical transmission of Helicobacter pylori in an experimental murine model
por: Lee, Jin-Uk, et al.
Publicado: (2006)

Helicobacter pylori : revisión bibliográfica
por: Gómez Morayta, Enrique
Publicado: (2003)

Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo
por: Hicks, Amy N., et al.
Publicado: (2012)

Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response
por: Mao, X R, et al.
Publicado: (2016)

Biophysical and enzymatic properties of aminoglycoside adenylyltransferase AadA6 from Pseudomonas aeruginosa
por: Papadovasilaki, Maria, et al.
Publicado: (2015)

The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions
por: Fortunato, Carlo, et al.
Publicado: (2021)

Functional Characterization, Mechanism, and Mode of Action of Putative Streptomycin Adenylyltransferase from Serratia marcescens
por: Prabhu, Dhamodharan, et al.
Publicado: (2022)

Mucosa-Associated Lymphoid Tissue Lymphoma of the Sigmoid Colon Discovered on Routine Screening Colonoscopy in Patient with Hepatitis C and Helicobacter pylori Infection
por: Bhuta, Rajiv, et al.
Publicado: (2016)

Helicobacter Pylori and Gastric Cancer: Clinical Aspects
por: Song, Zhi-Qiang, et al.
Publicado: (2015)

Helicobacter pylori and hormones.
por: Calam, J.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_6sm27nu047hnkdl56t93c3ual4