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Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

Chitinase inhibitors have chemotherapeutic potential as fungicides, pesticides, and antiasthmatics. Argifin, a natural product cyclopentapeptide, competitively inhibits family 18 chitinases in the nanomolar to micromolar range and shows extensive substrate mimicry. In an attempt to map the active fr...

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Detalles Bibliográficos
Autores principales:	Andersen, Ole A., Nathubhai, Amit, Dixon, Mark J., Eggleston, Ian M., van Aalten, Daan M.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764403/ https://www.ncbi.nlm.nih.gov/pubmed/18355729 http://dx.doi.org/10.1016/j.chembiol.2008.02.015

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