A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with...

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Detalles Bibliográficos
Autores principales: Smallbone, Kieran, Messiha, Hanan L., Carroll, Kathleen M., Winder, Catherine L., Malys, Naglis, Dunn, Warwick B., Murabito, Ettore, Swainston, Neil, Dada, Joseph O., Khan, Farid, Pir, Pınar, Simeonidis, Evangelos, Spasić, Irena, Wishart, Jill, Weichart, Dieter, Hayes, Neil W., Jameson, Daniel, Broomhead, David S., Oliver, Stephen G., Gaskell, Simon J., McCarthy, John E.G., Paton, Norman W., Westerhoff, Hans V., Kell, Douglas B., Mendes, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764422/
https://www.ncbi.nlm.nih.gov/pubmed/23831062
http://dx.doi.org/10.1016/j.febslet.2013.06.043

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