Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology

Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevan...

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Detalles Bibliográficos
Autores principales: Rowe, Martin, Kelly, Gemma L., Bell, Andrew I., Rickinson, Alan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764430/
https://www.ncbi.nlm.nih.gov/pubmed/19619657
http://dx.doi.org/10.1016/j.semcancer.2009.07.004
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author Rowe, Martin
Kelly, Gemma L.
Bell, Andrew I.
Rickinson, Alan B.
author_facet Rowe, Martin
Kelly, Gemma L.
Bell, Andrew I.
Rickinson, Alan B.
author_sort Rowe, Martin
collection PubMed
description Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma.
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spelling pubmed-37644302013-09-09 Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology Rowe, Martin Kelly, Gemma L. Bell, Andrew I. Rickinson, Alan B. Semin Cancer Biol Review Epstein-Barr virus was originally identified in the tumour cells of a Burkitt's lymphoma, and was the first virus to be associated with the pathogenesis of a human cancer. Studies on the relationship of EBV with Burkitt's lymphoma have revealed important general principles that are relevant to other virus-associated cancers. In addition, the impact of such studies on the knowledge of EBV biology has been enormous. Here, we review some of the key historical observations arising from studies on Burkitt's lymphoma that have informed our understanding of EBV, and we summarise the current hypotheses regarding the role of EBV in the pathogenesis of Burkitt's lymphoma. Academic Press 2009-12 /pmc/articles/PMC3764430/ /pubmed/19619657 http://dx.doi.org/10.1016/j.semcancer.2009.07.004 Text en © 2009 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Rowe, Martin
Kelly, Gemma L.
Bell, Andrew I.
Rickinson, Alan B.
Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title_full Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title_fullStr Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title_full_unstemmed Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title_short Burkitt's lymphoma: The Rosetta Stone deciphering Epstein-Barr virus biology
title_sort burkitt's lymphoma: the rosetta stone deciphering epstein-barr virus biology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764430/
https://www.ncbi.nlm.nih.gov/pubmed/19619657
http://dx.doi.org/10.1016/j.semcancer.2009.07.004
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