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Distinct cell shapes determine accurate chemotaxis

The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes in amoeboid cells is more difficult as they lack these const...

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Autores principales: Tweedy, Luke, Meier, Börn, Stephan, Jürgen, Heinrich, Doris, Endres, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764443/
https://www.ncbi.nlm.nih.gov/pubmed/24008441
http://dx.doi.org/10.1038/srep02606
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author Tweedy, Luke
Meier, Börn
Stephan, Jürgen
Heinrich, Doris
Endres, Robert G.
author_facet Tweedy, Luke
Meier, Börn
Stephan, Jürgen
Heinrich, Doris
Endres, Robert G.
author_sort Tweedy, Luke
collection PubMed
description The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes in amoeboid cells is more difficult as they lack these constraints. Here, we examine cell shape and movement in starved Dictyostelium amoebae during migration toward a chemoattractant in a microfluidic chamber. We show that the incredible variety in amoeboid shape across a population can be reduced to a few modes of variation. Interestingly, cells use distinct modes depending on the applied chemical gradient, with specific cell shapes associated with shallow, difficult-to-sense gradients. Modelling and drug treatment reveals that these behaviours are intrinsically linked with accurate sensing at the physical limit. Since similar behaviours are observed in a diverse range of cell types, we propose that cell shape and behaviour are conserved traits.
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spelling pubmed-37644432013-09-09 Distinct cell shapes determine accurate chemotaxis Tweedy, Luke Meier, Börn Stephan, Jürgen Heinrich, Doris Endres, Robert G. Sci Rep Article The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes in amoeboid cells is more difficult as they lack these constraints. Here, we examine cell shape and movement in starved Dictyostelium amoebae during migration toward a chemoattractant in a microfluidic chamber. We show that the incredible variety in amoeboid shape across a population can be reduced to a few modes of variation. Interestingly, cells use distinct modes depending on the applied chemical gradient, with specific cell shapes associated with shallow, difficult-to-sense gradients. Modelling and drug treatment reveals that these behaviours are intrinsically linked with accurate sensing at the physical limit. Since similar behaviours are observed in a diverse range of cell types, we propose that cell shape and behaviour are conserved traits. Nature Publishing Group 2013-09-06 /pmc/articles/PMC3764443/ /pubmed/24008441 http://dx.doi.org/10.1038/srep02606 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Tweedy, Luke
Meier, Börn
Stephan, Jürgen
Heinrich, Doris
Endres, Robert G.
Distinct cell shapes determine accurate chemotaxis
title Distinct cell shapes determine accurate chemotaxis
title_full Distinct cell shapes determine accurate chemotaxis
title_fullStr Distinct cell shapes determine accurate chemotaxis
title_full_unstemmed Distinct cell shapes determine accurate chemotaxis
title_short Distinct cell shapes determine accurate chemotaxis
title_sort distinct cell shapes determine accurate chemotaxis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764443/
https://www.ncbi.nlm.nih.gov/pubmed/24008441
http://dx.doi.org/10.1038/srep02606
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