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Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
BACKGROUND: Aggregation of the α-Synuclein (α-Syn) protein, amyloid fibril formation and progressive neurodegeneration are the neuropathological hallmarks of Parkinson's Disease (PD). However, a detailed mechanism of α-Syn aggregation/fibrillogenesis and the exact nature of toxic oligomeric spe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764494/ https://www.ncbi.nlm.nih.gov/pubmed/23339399 http://dx.doi.org/10.1186/1750-1326-8-5 |