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Spatial Control of DNA Reaction Networks by DNA Sequence
We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764599/ https://www.ncbi.nlm.nih.gov/pubmed/23143151 http://dx.doi.org/10.3390/molecules171113390 |
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author | Allen, Peter B. Chen, Xi Ellington, Andrew D. |
author_facet | Allen, Peter B. Chen, Xi Ellington, Andrew D. |
author_sort | Allen, Peter B. |
collection | PubMed |
description | We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns. |
format | Online Article Text |
id | pubmed-3764599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37645992013-09-06 Spatial Control of DNA Reaction Networks by DNA Sequence Allen, Peter B. Chen, Xi Ellington, Andrew D. Molecules Article We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns. MDPI 2012-11-09 /pmc/articles/PMC3764599/ /pubmed/23143151 http://dx.doi.org/10.3390/molecules171113390 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Allen, Peter B. Chen, Xi Ellington, Andrew D. Spatial Control of DNA Reaction Networks by DNA Sequence |
title | Spatial Control of DNA Reaction Networks by DNA Sequence |
title_full | Spatial Control of DNA Reaction Networks by DNA Sequence |
title_fullStr | Spatial Control of DNA Reaction Networks by DNA Sequence |
title_full_unstemmed | Spatial Control of DNA Reaction Networks by DNA Sequence |
title_short | Spatial Control of DNA Reaction Networks by DNA Sequence |
title_sort | spatial control of dna reaction networks by dna sequence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764599/ https://www.ncbi.nlm.nih.gov/pubmed/23143151 http://dx.doi.org/10.3390/molecules171113390 |
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