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Spatial Control of DNA Reaction Networks by DNA Sequence

We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the...

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Detalles Bibliográficos
Autores principales: Allen, Peter B., Chen, Xi, Ellington, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764599/
https://www.ncbi.nlm.nih.gov/pubmed/23143151
http://dx.doi.org/10.3390/molecules171113390
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author Allen, Peter B.
Chen, Xi
Ellington, Andrew D.
author_facet Allen, Peter B.
Chen, Xi
Ellington, Andrew D.
author_sort Allen, Peter B.
collection PubMed
description We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns.
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spelling pubmed-37645992013-09-06 Spatial Control of DNA Reaction Networks by DNA Sequence Allen, Peter B. Chen, Xi Ellington, Andrew D. Molecules Article We have developed a set of DNA circuits that execute during gel electrophoresis to yield immobile, fluorescent features in the gel. The parallel execution of orthogonal circuits led to the simultaneous production of different fluorescent lines at different positions in the gel. The positions of the lines could be rationally manipulated by changing the mobilities of the reactants. The ability to program at the nanoscale so as to produce patterns at the macroscale is a step towards programmable, synthetic chemical systems for generating defined spatiotemporal patterns. MDPI 2012-11-09 /pmc/articles/PMC3764599/ /pubmed/23143151 http://dx.doi.org/10.3390/molecules171113390 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Allen, Peter B.
Chen, Xi
Ellington, Andrew D.
Spatial Control of DNA Reaction Networks by DNA Sequence
title Spatial Control of DNA Reaction Networks by DNA Sequence
title_full Spatial Control of DNA Reaction Networks by DNA Sequence
title_fullStr Spatial Control of DNA Reaction Networks by DNA Sequence
title_full_unstemmed Spatial Control of DNA Reaction Networks by DNA Sequence
title_short Spatial Control of DNA Reaction Networks by DNA Sequence
title_sort spatial control of dna reaction networks by dna sequence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764599/
https://www.ncbi.nlm.nih.gov/pubmed/23143151
http://dx.doi.org/10.3390/molecules171113390
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