Cargando…

Metalloid compounds as drugs

The six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arse...

Descripción completa

Detalles Bibliográficos
Autor principal: Sekhon, B. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764666/
https://www.ncbi.nlm.nih.gov/pubmed/24019824
_version_ 1782283168080986112
author Sekhon, B. S.
author_facet Sekhon, B. S.
author_sort Sekhon, B. S.
collection PubMed
description The six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis. Arsenic trioxide has been approved for the treatment of acute promyelocytic leukemia. Pentavalent antimonials have been the recommended drug for visceral leishmaniasis and cutaneous leishmaniasis. Tellurium (IV) compounds may have important roles in thiol redox biological activity in the human body, and ammonium trichloro (dioxoethylene-O, O’-)tellurate (AS101) may be a promising agent for the treatment of Parkinson’s disease. Organosilicon compounds have been shown to be effective in vitro multidrug-resistance reverting agents.
format Online
Article
Text
id pubmed-3764666
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37646662013-09-09 Metalloid compounds as drugs Sekhon, B. S. Res Pharm Sci Review Article The six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis. Arsenic trioxide has been approved for the treatment of acute promyelocytic leukemia. Pentavalent antimonials have been the recommended drug for visceral leishmaniasis and cutaneous leishmaniasis. Tellurium (IV) compounds may have important roles in thiol redox biological activity in the human body, and ammonium trichloro (dioxoethylene-O, O’-)tellurate (AS101) may be a promising agent for the treatment of Parkinson’s disease. Organosilicon compounds have been shown to be effective in vitro multidrug-resistance reverting agents. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3764666/ /pubmed/24019824 Text en Copyright: © Journal of Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sekhon, B. S.
Metalloid compounds as drugs
title Metalloid compounds as drugs
title_full Metalloid compounds as drugs
title_fullStr Metalloid compounds as drugs
title_full_unstemmed Metalloid compounds as drugs
title_short Metalloid compounds as drugs
title_sort metalloid compounds as drugs
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764666/
https://www.ncbi.nlm.nih.gov/pubmed/24019824
work_keys_str_mv AT sekhonbs metalloidcompoundsasdrugs