Cargando…
In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract
Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764866/ https://www.ncbi.nlm.nih.gov/pubmed/24049415 http://dx.doi.org/10.4103/0974-8520.115446 |
_version_ | 1782283194685456384 |
---|---|
author | Ganeshpurkar, Aditya Diwedi, Varsha Bhardwaj, Yash |
author_facet | Ganeshpurkar, Aditya Diwedi, Varsha Bhardwaj, Yash |
author_sort | Ganeshpurkar, Aditya |
collection | PubMed |
description | Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it. |
format | Online Article Text |
id | pubmed-3764866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37648662013-09-18 In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract Ganeshpurkar, Aditya Diwedi, Varsha Bhardwaj, Yash Ayu Pharmacological Study Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3764866/ /pubmed/24049415 http://dx.doi.org/10.4103/0974-8520.115446 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pharmacological Study Ganeshpurkar, Aditya Diwedi, Varsha Bhardwaj, Yash In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title | In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title_full | In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title_fullStr | In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title_full_unstemmed | In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title_short | In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract |
title_sort | in vitro α -amylase and α-glucosidase inhibitory potential of trigonella foenum-graecum leaves extract |
topic | Pharmacological Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764866/ https://www.ncbi.nlm.nih.gov/pubmed/24049415 http://dx.doi.org/10.4103/0974-8520.115446 |
work_keys_str_mv | AT ganeshpurkaraditya invitroaamylaseandaglucosidaseinhibitorypotentialoftrigonellafoenumgraecumleavesextract AT diwedivarsha invitroaamylaseandaglucosidaseinhibitorypotentialoftrigonellafoenumgraecumleavesextract AT bhardwajyash invitroaamylaseandaglucosidaseinhibitorypotentialoftrigonellafoenumgraecumleavesextract |