Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy

BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have bee...

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Detalles Bibliográficos
Autores principales: Kolm, I., Pawlik, E., Eggmann, N., Kamarachev, J., Kerl, K., French, L.E., Hofbauer, G.F.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: August, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764944/
https://www.ncbi.nlm.nih.gov/pubmed/24019776
http://dx.doi.org/10.1159/000354721
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author Kolm, I.
Pawlik, E.
Eggmann, N.
Kamarachev, J.
Kerl, K.
French, L.E.
Hofbauer, G.F.L.
author_facet Kolm, I.
Pawlik, E.
Eggmann, N.
Kamarachev, J.
Kerl, K.
French, L.E.
Hofbauer, G.F.L.
author_sort Kolm, I.
collection PubMed
description BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity. CASE REPORT: We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer. DISCUSSION: The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance.
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spelling pubmed-37649442013-09-09 Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy Kolm, I. Pawlik, E. Eggmann, N. Kamarachev, J. Kerl, K. French, L.E. Hofbauer, G.F.L. Case Rep Dermatol Published online: August, 2013 BACKGROUND: The origin of collagen autoimmune diseases is not fully understood. Some studies postulate a mechanism of molecular mimicry or heterologous immunity following viral infections triggering autoimmunity. Apart from infections, other exogenous factors such as visible light or X-rays have been reported to incite autoimmunity. CASE REPORT: We report a case of histologically and serologically confirmed subacute lupus erythematosus (SCLE) following radiotherapy for breast cancer. DISCUSSION: The close temporal and spatial correlation between radiotherapy and onset of SCLE in this patient suggests that an autoimmune reaction may have been triggered locally by functionally altering the immune system and breaking self-tolerance. S. Karger AG 2013-08-17 /pmc/articles/PMC3764944/ /pubmed/24019776 http://dx.doi.org/10.1159/000354721 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: August, 2013
Kolm, I.
Pawlik, E.
Eggmann, N.
Kamarachev, J.
Kerl, K.
French, L.E.
Hofbauer, G.F.L.
Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title_full Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title_fullStr Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title_full_unstemmed Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title_short Subacute Cutaneous Lupus Erythematosus Triggered by Radiotherapy
title_sort subacute cutaneous lupus erythematosus triggered by radiotherapy
topic Published online: August, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764944/
https://www.ncbi.nlm.nih.gov/pubmed/24019776
http://dx.doi.org/10.1159/000354721
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