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Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy
Clinical staging determines antiretroviral therapy (ART) eligibility when CD4 count is not available. Haemoglobin (Hb) ≤8 g/dL is an indication for the treatment. We measured Hb in HIV-positive Malawian adults undergoing clinical assessment for ART eligibility and calculated the percentage of patien...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764951/ https://www.ncbi.nlm.nih.gov/pubmed/23970747 http://dx.doi.org/10.1177/0956462412472832 |
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author | Page, I D McKew, S J Kudzala, A G Fullwood, C van Oosterhout, J J Bates, I |
author_facet | Page, I D McKew, S J Kudzala, A G Fullwood, C van Oosterhout, J J Bates, I |
author_sort | Page, I D |
collection | PubMed |
description | Clinical staging determines antiretroviral therapy (ART) eligibility when CD4 count is not available. Haemoglobin (Hb) ≤8 g/dL is an indication for the treatment. We measured Hb in HIV-positive Malawian adults undergoing clinical assessment for ART eligibility and calculated the percentage of patients with CD4 ≤ 350 cells/μL deemed eligible for ART by clinical staging with and without Hb measurement, using the existing threshold and an alternative proposed after comparing Hb values to CD4 counts. Three hundred and thirty-eight patients had CD4 counts measured and 226 (67%) had CD4 ≤ 350 cells/μL. Thirty-six (16%) patients with low CD4 count were eligible for ART by clinical assessment alone, 48 (21%) when Hb was also measured with a threshold of ≤8 g/dL and 74 (34%) with a threshold of ≤10 g/dL. Measuring Hb alongside clinical assessment could increase the number of patients with CD4 ≤ 350 cells/μL starting ART by 33% using a threshold of Hb ≤ 8 g/dL or 114% with a threshold of ≤10g/dL. |
format | Online Article Text |
id | pubmed-3764951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-37649512013-09-09 Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy Page, I D McKew, S J Kudzala, A G Fullwood, C van Oosterhout, J J Bates, I Int J STD AIDS Original Research Articles Clinical staging determines antiretroviral therapy (ART) eligibility when CD4 count is not available. Haemoglobin (Hb) ≤8 g/dL is an indication for the treatment. We measured Hb in HIV-positive Malawian adults undergoing clinical assessment for ART eligibility and calculated the percentage of patients with CD4 ≤ 350 cells/μL deemed eligible for ART by clinical staging with and without Hb measurement, using the existing threshold and an alternative proposed after comparing Hb values to CD4 counts. Three hundred and thirty-eight patients had CD4 counts measured and 226 (67%) had CD4 ≤ 350 cells/μL. Thirty-six (16%) patients with low CD4 count were eligible for ART by clinical assessment alone, 48 (21%) when Hb was also measured with a threshold of ≤8 g/dL and 74 (34%) with a threshold of ≤10 g/dL. Measuring Hb alongside clinical assessment could increase the number of patients with CD4 ≤ 350 cells/μL starting ART by 33% using a threshold of Hb ≤ 8 g/dL or 114% with a threshold of ≤10g/dL. SAGE Publications 2013-06 /pmc/articles/PMC3764951/ /pubmed/23970747 http://dx.doi.org/10.1177/0956462412472832 Text en © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav http://creativecommons.org/licenses/by-nc/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Articles Page, I D McKew, S J Kudzala, A G Fullwood, C van Oosterhout, J J Bates, I Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title | Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title_full | Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title_fullStr | Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title_full_unstemmed | Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title_short | Screening HIV-infected adults in Malawi for anaemia: impact on eligibility for antiretroviral therapy |
title_sort | screening hiv-infected adults in malawi for anaemia: impact on eligibility for antiretroviral therapy |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764951/ https://www.ncbi.nlm.nih.gov/pubmed/23970747 http://dx.doi.org/10.1177/0956462412472832 |
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