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Fate of TLR-1/TLR-2 agonist functionalised pDNA nanoparticles upon deposition at the human bronchial epithelium in vitro

BACKGROUND: Plasmid DNA vaccination is a promising approach, but studies in non-human primates and humans failed to achieve protective immunity. To optimise this technology further with focus on pulmonary administration, we developed and evaluated an adjuvant-equipped DNA carrier system based on the...

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Detalles Bibliográficos
Autores principales:	Heuking, Simon, Rothen-Rutishauser, Barbara, Raemy, David Olivier, Gehr, Peter, Borchard, Gerrit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765319/ https://www.ncbi.nlm.nih.gov/pubmed/23964697 http://dx.doi.org/10.1186/1477-3155-11-29

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