The Newly Developed CRF(1)-Receptor Antagonists, NGD 98-2 and NGD 9002, Suppress Acute Stress-Induced Stimulation of Colonic Motor Function and Visceral Hypersensitivity in Rats

Corticotropin releasing factor receptor 1 (CRF(1)) is the key receptor that mediates stress-related body responses. However to date there are no CRF(1) antagonists that have shown clinical efficacy in stress-related diseases. We investigated the inhibitory effects of a new generation, topology 2 sel...

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Detalles Bibliográficos
Autores principales: Million, Mulugeta, Zhao, Jing-Fang, Luckey, Andrew, Czimmer, József, Maynard, George D., Kehne, John, Hoffman, Diane C., Taché, Yvette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765344/
https://www.ncbi.nlm.nih.gov/pubmed/24040053
http://dx.doi.org/10.1371/journal.pone.0073749

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