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Levothyroxine and lung cancer in females: the importance of oxidative stress

BACKGROUND: Levothyroxine (LT(4)) treatment can lead to iatrogenic hyperthyroidism and oxidative stress that can cause patient discomfort. Oxidative stress is also recognized as one of the causes of chronic diseases and cancer. METHODS: The prevalence of breast, colorectal, gastric and lung cancer i...

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Autores principales: Cornelli, Umberto, Belcaro, Gianni, Recchia, Martino, Finco, Annarosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765368/
https://www.ncbi.nlm.nih.gov/pubmed/23924086
http://dx.doi.org/10.1186/1477-7827-11-75
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author Cornelli, Umberto
Belcaro, Gianni
Recchia, Martino
Finco, Annarosa
author_facet Cornelli, Umberto
Belcaro, Gianni
Recchia, Martino
Finco, Annarosa
author_sort Cornelli, Umberto
collection PubMed
description BACKGROUND: Levothyroxine (LT(4)) treatment can lead to iatrogenic hyperthyroidism and oxidative stress that can cause patient discomfort. Oxidative stress is also recognized as one of the causes of chronic diseases and cancer. METHODS: The prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 was correlated with the sales of LT(4) in 2009. The cancer prevalence was analyzed in women aged 30–84. This age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers. The correlation between sales of LT(4) and cancers was determined with the technique of Density Ellipses. The age and smoking contribution for lung cancer was determined with the Sequential test. RESULTS: No significant correlation was seen between LT(4) sales and breast, colorectal and gastric cancers. A significant correlation was instead found for lung cancer (p < 0.05) corrected for smoking and age. CONCLUSIONS: LT(4) consumption in Italy is about 0.7 boxes/women/year. There is a correlation between lung cancer and LT(4) treatment and oxidative stress caused by LT(4) supplementation can be one of the causes. Although we cannot exclude that dysthyroidism needing LT(4) supplementation might be the ground for lung cancer itself and measuring oxidative stress could be helpful in avoiding excessive use of the drug.
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spelling pubmed-37653682013-09-07 Levothyroxine and lung cancer in females: the importance of oxidative stress Cornelli, Umberto Belcaro, Gianni Recchia, Martino Finco, Annarosa Reprod Biol Endocrinol Research BACKGROUND: Levothyroxine (LT(4)) treatment can lead to iatrogenic hyperthyroidism and oxidative stress that can cause patient discomfort. Oxidative stress is also recognized as one of the causes of chronic diseases and cancer. METHODS: The prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 was correlated with the sales of LT(4) in 2009. The cancer prevalence was analyzed in women aged 30–84. This age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers. The correlation between sales of LT(4) and cancers was determined with the technique of Density Ellipses. The age and smoking contribution for lung cancer was determined with the Sequential test. RESULTS: No significant correlation was seen between LT(4) sales and breast, colorectal and gastric cancers. A significant correlation was instead found for lung cancer (p < 0.05) corrected for smoking and age. CONCLUSIONS: LT(4) consumption in Italy is about 0.7 boxes/women/year. There is a correlation between lung cancer and LT(4) treatment and oxidative stress caused by LT(4) supplementation can be one of the causes. Although we cannot exclude that dysthyroidism needing LT(4) supplementation might be the ground for lung cancer itself and measuring oxidative stress could be helpful in avoiding excessive use of the drug. BioMed Central 2013-08-08 /pmc/articles/PMC3765368/ /pubmed/23924086 http://dx.doi.org/10.1186/1477-7827-11-75 Text en Copyright © 2013 Cornelli et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Cornelli, Umberto
Belcaro, Gianni
Recchia, Martino
Finco, Annarosa
Levothyroxine and lung cancer in females: the importance of oxidative stress
title Levothyroxine and lung cancer in females: the importance of oxidative stress
title_full Levothyroxine and lung cancer in females: the importance of oxidative stress
title_fullStr Levothyroxine and lung cancer in females: the importance of oxidative stress
title_full_unstemmed Levothyroxine and lung cancer in females: the importance of oxidative stress
title_short Levothyroxine and lung cancer in females: the importance of oxidative stress
title_sort levothyroxine and lung cancer in females: the importance of oxidative stress
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765368/
https://www.ncbi.nlm.nih.gov/pubmed/23924086
http://dx.doi.org/10.1186/1477-7827-11-75
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