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In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway
BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3. However, relatively little is known about the regulation of these MMPs in the...
Autores principales: | Green, Justin A, Rand, Lucinda, Moores, Rachel, Dholakia, Shruti, Pezas, Theodore, Elkington, Paul T, Friedland, Jon S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765428/ https://www.ncbi.nlm.nih.gov/pubmed/23978194 http://dx.doi.org/10.1186/1742-2094-10-107 |
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