M(o)TOR of aging: MTOR as a universal molecular hypothalamus

A recent ground-breaking publication described hypothalamus-driven programmatic aging. As a Russian proverb goes “everything new is well-forgotten old”. In 1958, Dilman proposed that aging and its related diseases are programmed by the hypothalamus. This theory, supported by beautiful experiments, r...

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Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765577/
https://www.ncbi.nlm.nih.gov/pubmed/23872658
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description A recent ground-breaking publication described hypothalamus-driven programmatic aging. As a Russian proverb goes “everything new is well-forgotten old”. In 1958, Dilman proposed that aging and its related diseases are programmed by the hypothalamus. This theory, supported by beautiful experiments, remained unnoticed just to be re-discovered recently. Yet, it does not explain all manifestations of aging. And would organism age without hypothalamus? Do sensing pathways such as MTOR (mechanistic Target of Rapamycin) and IKK-beta play a role of a “molecular hypothalamus” in every cell? Are hypothalamus-driven alterations simply a part of quasi-programmed aging manifested by hyperfunction and secondary signal-resistance? Here are some answers.
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spelling pubmed-37655772013-09-10 M(o)TOR of aging: MTOR as a universal molecular hypothalamus Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective A recent ground-breaking publication described hypothalamus-driven programmatic aging. As a Russian proverb goes “everything new is well-forgotten old”. In 1958, Dilman proposed that aging and its related diseases are programmed by the hypothalamus. This theory, supported by beautiful experiments, remained unnoticed just to be re-discovered recently. Yet, it does not explain all manifestations of aging. And would organism age without hypothalamus? Do sensing pathways such as MTOR (mechanistic Target of Rapamycin) and IKK-beta play a role of a “molecular hypothalamus” in every cell? Are hypothalamus-driven alterations simply a part of quasi-programmed aging manifested by hyperfunction and secondary signal-resistance? Here are some answers. Impact Journals LLC 2013-07-16 /pmc/articles/PMC3765577/ /pubmed/23872658 Text en Copyright: © 2013 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Blagosklonny, Mikhail V.
M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title_full M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title_fullStr M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title_full_unstemmed M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title_short M(o)TOR of aging: MTOR as a universal molecular hypothalamus
title_sort m(o)tor of aging: mtor as a universal molecular hypothalamus
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765577/
https://www.ncbi.nlm.nih.gov/pubmed/23872658
work_keys_str_mv AT blagosklonnymikhailv motorofagingmtorasauniversalmolecularhypothalamus

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