Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility in humans. The canonical target of rapamycin, and the one thought to account for its effects on lifespan, is the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). We ha...

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Detalles Bibliográficos
Autores principales: Ye, Lan, Widlund, Anne L., Sims, Carrie A., Lamming, Dudley W., Guan, Yuxia, Davis, James G., Sabatini, David M., Harrison, David E., Vang, Ole, Baur, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765582/
https://www.ncbi.nlm.nih.gov/pubmed/23929887

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