Cargando…

Structures of human PKG reveal cGMP-selectived activation mechanisms

Detalles Bibliográficos
Autores principales:	Huang, Gilbert Y, Kim, Jeong J, Reger, Albert S, Lorenz, Robin, Moon, Eui-Whan, Zhao, Chi, Casteel, Darren E, Bertinetti, Daniela, VanSchouwen, Bryan, Selvaratnam, Rajeevan, Pflugrath, James W, Sankaran, Banumathi, Melacini, Giuseppe, Herberg, Friedrich W, Kim, Choel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Oral Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765643/ http://dx.doi.org/10.1186/2050-6511-14-S1-O16

Ejemplares similares

Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity
por: Lorenz, Robin, et al.
Publicado: (2013)

Crystal structures of the carboxyl cGMP binding domain of plasmodium falciparum cGMP-dependent protein kinase reveals a novel salt bridge crucial for activation
por: Kim, Jeong Joo, et al.
Publicado: (2013)

An auto-inhibited state of protein kinase G and implications for selective activation
por: Sharma, Rajesh, et al.
Publicado: (2022)

The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009)

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design
por: Huang, Gilbert Y., et al.
Publicado: (2014)

Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum
por: Calamera, Gaia, et al.
Publicado: (2015)

The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase
por: Franz, Eugen, et al.
Publicado: (2015)

Role of cGMP/PKG in fat tissue
por: Pfeifer, Alexander
Publicado: (2011)

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress
por: Kim, Jeong Joo, et al.
Publicado: (2015)

Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II
por: Campbell, James C, et al.
Publicado: (2015)

The crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding
por: Kim, Jeong Joo, et al.
Publicado: (2011)

Rational design of a PKA-based sensor for cGMP
por: Lorenz, Robin, et al.
Publicado: (2015)

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
por: Kim, Jeong Joo, et al.
Publicado: (2011)

Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex
por: Rangaswami, Hema, et al.
Publicado: (2011)

cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
por: Park, Min, et al.
Publicado: (2018)

The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies
por: Cai, Zhulan, et al.
Publicado: (2023)

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function
por: Gambaryan, Stepan
Publicado: (2022)

Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly
por: Kim, Choel, et al.
Publicado: (2020)

New cGMP analogues restrain proliferation and migration of melanoma cells
por: Vighi, Eleonora, et al.
Publicado: (2017)

PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis
por: Lopes-Pires, M. Elisa, et al.
Publicado: (2015)

The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
por: Degjoni, Anisa, et al.
Publicado: (2022)

Heart Failure With Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women
por: Sinha, Arjun, et al.
Publicado: (2020)

Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway
por: Lv, Jinpeng, et al.
Publicado: (2020)

The first crystal structure of cyclic GMP-dependent protein kinase Iβ dimerization/docking domain reveals molecular details of isoform-specific anchoring
por: Casteel, Darren E, et al.
Publicado: (2009)

Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states
por: Byun, Jung Ah, et al.
Publicado: (2020)

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
por: Tawa, Paul, et al.
Publicado: (2022)

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway
por: Kinoshita, Hideyuki, et al.
Publicado: (2009)

Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?
por: Kovács, Á., et al.
Publicado: (2016)

Nitric Oxide Enhances Keratinocyte Cell Migration by Regulating Rho GTPase via cGMP-PKG Signalling
por: Zhan, Rixing, et al.
Publicado: (2015)

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway
por: Wen, Jake J., et al.
Publicado: (2020)

Swimming exercise inhibits myocardial ER stress in the hearts of aged mice by enhancing cGMP-PKG signaling
por: Chang, Pan, et al.
Publicado: (2020)

Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration
por: Roy, Akanksha, et al.
Publicado: (2022)

Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock
por: Plano, Santiago Andrés, et al.
Publicado: (2021)

Myocardial stretch-induced compliance is abrogated under ischemic conditions and restored by cGMP/PKG-related pathways
por: Leite-Moreira, André M., et al.
Publicado: (2023)

FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
por: Calamera, Gaia, et al.
Publicado: (2019)

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain
por: Ding, Yuanyuan, et al.
Publicado: (2017)

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
por: VerPlank, Jordan J. S., et al.
Publicado: (2020)

Allosteric pluripotency as revealed by protein kinase A
por: Byun, J. A., et al.
Publicado: (2020)

Divergent allostery reveals critical differences between structurally homologous regulatory domains of Plasmodium falciparum and human protein kinase G
por: Byun, Jung Ah, et al.
Publicado: (2022)

Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
por: Lee, Jia Hai, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_q7ur7avlk460hdipfkn1h0e16i