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A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysideaherbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment

The ethanol extract of an Indonesian marine sponge Lamellodysidea herbacea inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), an important target enzyme for the treatment of type II diabetes. Bioassay-guided isolation yielded a known polybromodiphenyl ether (1) as a sole bioactive co...

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Detalles Bibliográficos
Autores principales:	Yamazaki, Hiroyuki, Sumilat, Deiske A., Kanno, Syu-ichi, Ukai, Kazuyo, Rotinsulu, Henki, Wewengkang, Defny S., Ishikawa, Masaaki, Mangindaan, Remy E. P., Namikoshi, Michio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Japan 2012
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765847/ https://www.ncbi.nlm.nih.gov/pubmed/23274914 http://dx.doi.org/10.1007/s11418-012-0735-y

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