S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

BACKGROUND: Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We hypothesized that oxidative posttranslational modification of parkin by enviro...

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Detalles Bibliográficos
Autores principales: Sunico, Carmen R, Nakamura, Tomohiro, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Chan, Shing Fai, Newmeyer, Traci Fang, Masliah, Eliezer, Nakanishi, Nobuki, Lipton, Stuart A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765907/
https://www.ncbi.nlm.nih.gov/pubmed/23985028
http://dx.doi.org/10.1186/1750-1326-8-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765907/
https://www.ncbi.nlm.nih.gov/pubmed/23985028
http://dx.doi.org/10.1186/1750-1326-8-29

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