Cargando…
All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010
BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) comp...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765919/ https://www.ncbi.nlm.nih.gov/pubmed/23961924 http://dx.doi.org/10.1186/1471-2334-13-382 |
_version_ | 1782283421775560704 |
---|---|
author | Hernando, Victoria Alejos, Belen Monge, Susana Berenguer, Juan Anta, Lourdes Vinuesa, David Palacios, Rosario Muga, Roberto Moreno, Santiago Jarrin, Inma |
author_facet | Hernando, Victoria Alejos, Belen Monge, Susana Berenguer, Juan Anta, Lourdes Vinuesa, David Palacios, Rosario Muga, Roberto Moreno, Santiago Jarrin, Inma |
author_sort | Hernando, Victoria |
collection | PubMed |
description | BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. METHODS: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. RESULTS: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997–2003). CONCLUSION: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection. |
format | Online Article Text |
id | pubmed-3765919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37659192013-09-08 All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 Hernando, Victoria Alejos, Belen Monge, Susana Berenguer, Juan Anta, Lourdes Vinuesa, David Palacios, Rosario Muga, Roberto Moreno, Santiago Jarrin, Inma BMC Infect Dis Research Article BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. METHODS: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. RESULTS: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997–2003). CONCLUSION: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection. BioMed Central 2013-08-20 /pmc/articles/PMC3765919/ /pubmed/23961924 http://dx.doi.org/10.1186/1471-2334-13-382 Text en Copyright © 2013 Hernando et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hernando, Victoria Alejos, Belen Monge, Susana Berenguer, Juan Anta, Lourdes Vinuesa, David Palacios, Rosario Muga, Roberto Moreno, Santiago Jarrin, Inma All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title | All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title_full | All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title_fullStr | All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title_full_unstemmed | All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title_short | All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997–2010 |
title_sort | all-cause mortality in the cohorts of the spanish aids research network (ris) compared with the general population: 1997–2010 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765919/ https://www.ncbi.nlm.nih.gov/pubmed/23961924 http://dx.doi.org/10.1186/1471-2334-13-382 |
work_keys_str_mv | AT hernandovictoria allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT alejosbelen allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT mongesusana allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT berenguerjuan allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT antalourdes allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT vinuesadavid allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT palaciosrosario allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT mugaroberto allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT morenosantiago allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 AT jarrininma allcausemortalityinthecohortsofthespanishaidsresearchnetworkriscomparedwiththegeneralpopulation19972010 |