FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos and is linked with pluripotency. Inhibition of Erk1/2 and Gsk3β signaling in mouse embryonic stem cells (ESCs) by small-molecule inhibitors (called 2i) has recently been shown to induce hypomethylati...

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Detalles Bibliográficos
Autores principales: Ficz, Gabriella, Hore, Timothy A., Santos, Fátima, Lee, Heather J., Dean, Wendy, Arand, Julia, Krueger, Felix, Oxley, David, Paul, Yu-Lee, Walter, Jörn, Cook, Simon J., Andrews, Simon, Branco, Miguel R., Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765959/
https://www.ncbi.nlm.nih.gov/pubmed/23850245
http://dx.doi.org/10.1016/j.stem.2013.06.004

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