Aetiology of biliary atresia: what is actually known?

Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic research has bee...

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Detalles Bibliográficos
Autores principales: Petersen, Claus, Davenport, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766137/
https://www.ncbi.nlm.nih.gov/pubmed/23987231
http://dx.doi.org/10.1186/1750-1172-8-128
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author Petersen, Claus
Davenport, Mark
author_facet Petersen, Claus
Davenport, Mark
author_sort Petersen, Claus
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description Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic research has been directed at elucidating the origin and pathology of BA. This review summarizes the current clinical variations of BA in humans, its occasional appearance in animals and its various manifestations in the laboratory as an experimental model.
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spelling pubmed-37661372013-09-08 Aetiology of biliary atresia: what is actually known? Petersen, Claus Davenport, Mark Orphanet J Rare Dis Review Biliary atresia (BA) is a rare disease of unknown etiology and unpredictable outcome, even when there has been timely diagnosis and exemplary surgery. It has been the commonest indication for liver transplantation during childhood for the past 20 years. Hence much clinical and basic research has been directed at elucidating the origin and pathology of BA. This review summarizes the current clinical variations of BA in humans, its occasional appearance in animals and its various manifestations in the laboratory as an experimental model. BioMed Central 2013-08-29 /pmc/articles/PMC3766137/ /pubmed/23987231 http://dx.doi.org/10.1186/1750-1172-8-128 Text en Copyright © 2013 Petersen and Davenport; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Petersen, Claus
Davenport, Mark
Aetiology of biliary atresia: what is actually known?
title Aetiology of biliary atresia: what is actually known?
title_full Aetiology of biliary atresia: what is actually known?
title_fullStr Aetiology of biliary atresia: what is actually known?
title_full_unstemmed Aetiology of biliary atresia: what is actually known?
title_short Aetiology of biliary atresia: what is actually known?
title_sort aetiology of biliary atresia: what is actually known?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766137/
https://www.ncbi.nlm.nih.gov/pubmed/23987231
http://dx.doi.org/10.1186/1750-1172-8-128
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