Cargando…

Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer

We retrospectively evaluated the risk of second malignancies among 832 patients with inner or central breast cancer treated with conventional external beam schedule (CRT group), or neutron brachytherapy using Californium-252 ((252)Cf) sources and hypofractionated external beam radiotherapy (HRTC gro...

Descripción completa

Detalles Bibliográficos
Autores principales: Valuckas, Konstantinas Povilas, Atkocius, Vydmantas, Kuzmickiene, Irena, Aleknavicius, Eduardas, Liukpetryte, Sarune, Ostapenko, Valerijus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766283/
https://www.ncbi.nlm.nih.gov/pubmed/23397075
http://dx.doi.org/10.1093/jrr/rrt009
_version_ 1782283505106944000
author Valuckas, Konstantinas Povilas
Atkocius, Vydmantas
Kuzmickiene, Irena
Aleknavicius, Eduardas
Liukpetryte, Sarune
Ostapenko, Valerijus
author_facet Valuckas, Konstantinas Povilas
Atkocius, Vydmantas
Kuzmickiene, Irena
Aleknavicius, Eduardas
Liukpetryte, Sarune
Ostapenko, Valerijus
author_sort Valuckas, Konstantinas Povilas
collection PubMed
description We retrospectively evaluated the risk of second malignancies among 832 patients with inner or central breast cancer treated with conventional external beam schedule (CRT group), or neutron brachytherapy using Californium-252 ((252)Cf) sources and hypofractionated external beam radiotherapy (HRTC group), between 1987 and 1996 at the Institute of Oncology, Vilnius University. Patients were observed until the occurrences of death or development of a second malignancy, or until 31 December 2009, whichever was earlier. Median follow-up time was 10.4 years (range, 1.2–24.1 years). Risk of second primary cancers was quantified using standardized incidence ratios (SIRs). Cox proportional hazards regression models were used to estimate hazard ratios (HRs). There was a significant increase in the risk of second primary cancers compared with the general population (SIR 1.3, 95% CI 1.1–1.5). The observed number of second primary cancers was also higher than expected for breast (SIR 1.8, 95% CI 1.3–2.4) and lung cancer (SIR 3.8, 95% CI 2.0–6.7). For second breast cancer, no raised relative risk was observed during the period ≥10 or more years after radiotherapy. Compared with the CRT group, HRTC patients had a not statistically significant higher risk of breast cancer. Increased relative risks were observed specifically for age at initial diagnosis of <50 years (HR 2.9, 95% CI 1.6–5.2) and for obesity (HR 2.8, 95% CI 1.1–7.2).
format Online
Article
Text
id pubmed-3766283
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-37662832013-09-09 Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer Valuckas, Konstantinas Povilas Atkocius, Vydmantas Kuzmickiene, Irena Aleknavicius, Eduardas Liukpetryte, Sarune Ostapenko, Valerijus J Radiat Res Oncology We retrospectively evaluated the risk of second malignancies among 832 patients with inner or central breast cancer treated with conventional external beam schedule (CRT group), or neutron brachytherapy using Californium-252 ((252)Cf) sources and hypofractionated external beam radiotherapy (HRTC group), between 1987 and 1996 at the Institute of Oncology, Vilnius University. Patients were observed until the occurrences of death or development of a second malignancy, or until 31 December 2009, whichever was earlier. Median follow-up time was 10.4 years (range, 1.2–24.1 years). Risk of second primary cancers was quantified using standardized incidence ratios (SIRs). Cox proportional hazards regression models were used to estimate hazard ratios (HRs). There was a significant increase in the risk of second primary cancers compared with the general population (SIR 1.3, 95% CI 1.1–1.5). The observed number of second primary cancers was also higher than expected for breast (SIR 1.8, 95% CI 1.3–2.4) and lung cancer (SIR 3.8, 95% CI 2.0–6.7). For second breast cancer, no raised relative risk was observed during the period ≥10 or more years after radiotherapy. Compared with the CRT group, HRTC patients had a not statistically significant higher risk of breast cancer. Increased relative risks were observed specifically for age at initial diagnosis of <50 years (HR 2.9, 95% CI 1.6–5.2) and for obesity (HR 2.8, 95% CI 1.1–7.2). Oxford University Press 2013-09 2013-02-07 /pmc/articles/PMC3766283/ /pubmed/23397075 http://dx.doi.org/10.1093/jrr/rrt009 Text en © The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Oncology
Valuckas, Konstantinas Povilas
Atkocius, Vydmantas
Kuzmickiene, Irena
Aleknavicius, Eduardas
Liukpetryte, Sarune
Ostapenko, Valerijus
Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title_full Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title_fullStr Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title_full_unstemmed Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title_short Second malignancies following conventional or combined (252)Cf neutron brachytherapy with external beam radiotherapy for breast cancer
title_sort second malignancies following conventional or combined (252)cf neutron brachytherapy with external beam radiotherapy for breast cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766283/
https://www.ncbi.nlm.nih.gov/pubmed/23397075
http://dx.doi.org/10.1093/jrr/rrt009
work_keys_str_mv AT valuckaskonstantinaspovilas secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer
AT atkociusvydmantas secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer
AT kuzmickieneirena secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer
AT aleknaviciuseduardas secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer
AT liukpetrytesarune secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer
AT ostapenkovalerijus secondmalignanciesfollowingconventionalorcombined252cfneutronbrachytherapywithexternalbeamradiotherapyforbreastcancer