Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra

BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was construct...

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Autores principales: Verma, Ankit, Sharma, Dhirendra Kumar, Sarma, Rituparna, Chetia, Hasnahana, Saikia, Juri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2013
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766306/
https://www.ncbi.nlm.nih.gov/pubmed/24023416
http://dx.doi.org/10.6026/97320630009755
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author Verma, Ankit
Sharma, Dhirendra Kumar
Sarma, Rituparna
Chetia, Hasnahana
Saikia, Juri
author_facet Verma, Ankit
Sharma, Dhirendra Kumar
Sarma, Rituparna
Chetia, Hasnahana
Saikia, Juri
author_sort Verma, Ankit
collection PubMed
description BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy.
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spelling pubmed-37663062013-09-10 Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra Verma, Ankit Sharma, Dhirendra Kumar Sarma, Rituparna Chetia, Hasnahana Saikia, Juri Bioinformation Hypothesis BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the homologous NGF (Nerve growth factor, another member of neuro-trophin family) from Naja atra. Comparative structural analysis of the models showed structural similarities with their predicted cavities for the interpretation of potential functional analogy. Biomedical Informatics 2013-08-28 /pmc/articles/PMC3766306/ /pubmed/24023416 http://dx.doi.org/10.6026/97320630009755 Text en © 2013 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Verma, Ankit
Sharma, Dhirendra Kumar
Sarma, Rituparna
Chetia, Hasnahana
Saikia, Juri
Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title_full Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title_fullStr Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title_full_unstemmed Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title_short Comparative insights using the molecular homology model of BDNF (Brain derived neurotrophic factor) of Varanus komodoensis and the known NGF (Nerve growth factor) structure of Naja atra
title_sort comparative insights using the molecular homology model of bdnf (brain derived neurotrophic factor) of varanus komodoensis and the known ngf (nerve growth factor) structure of naja atra
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766306/
https://www.ncbi.nlm.nih.gov/pubmed/24023416
http://dx.doi.org/10.6026/97320630009755
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