Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation

Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms....

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Detalles Bibliográficos
Autores principales: Estruch, Montserrat, Sánchez-Quesada, José Luis, Ordóñez Llanos, Jordi, Benítez, Sònia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766570/
https://www.ncbi.nlm.nih.gov/pubmed/24062611
http://dx.doi.org/10.1155/2013/181324
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author Estruch, Montserrat
Sánchez-Quesada, José Luis
Ordóñez Llanos, Jordi
Benítez, Sònia
author_facet Estruch, Montserrat
Sánchez-Quesada, José Luis
Ordóñez Llanos, Jordi
Benítez, Sònia
author_sort Estruch, Montserrat
collection PubMed
description Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect.
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spelling pubmed-37665702013-09-23 Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation Estruch, Montserrat Sánchez-Quesada, José Luis Ordóñez Llanos, Jordi Benítez, Sònia Mediators Inflamm Review Article Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect. Hindawi Publishing Corporation 2013 2013-08-22 /pmc/articles/PMC3766570/ /pubmed/24062611 http://dx.doi.org/10.1155/2013/181324 Text en Copyright © 2013 Montserrat Estruch et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Estruch, Montserrat
Sánchez-Quesada, José Luis
Ordóñez Llanos, Jordi
Benítez, Sònia
Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_full Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_fullStr Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_full_unstemmed Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_short Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation
title_sort electronegative ldl: a circulating modified ldl with a role in inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766570/
https://www.ncbi.nlm.nih.gov/pubmed/24062611
http://dx.doi.org/10.1155/2013/181324
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