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How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci

Invasive fungal infections, particularly those considered opportunistic, have become a common and significant complication of procedures performed in advanced contemporary medicine. Among such infections, cryptococcosis, which is usually caused by infection with Cryptococcus neoformans and Cryptococ...

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Autores principales: Okubo, Yoichiro, Tochigi, Naobumi, Wakayama, Megumi, Shinozaki, Minoru, Nakayama, Haruo, Ishiwatari, Takao, Shimodaira, Kayoko, Nemoto, Tetsuo, Ohno, Hideaki, Kaneko, Yukihiro, Makimura, Koichi, Uchida, Katsuhisa, Miyazaki, Yoshitsugu, Yamaguchi, Hideyo, Shibuya, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766597/
https://www.ncbi.nlm.nih.gov/pubmed/24058271
http://dx.doi.org/10.1155/2013/465319
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author Okubo, Yoichiro
Tochigi, Naobumi
Wakayama, Megumi
Shinozaki, Minoru
Nakayama, Haruo
Ishiwatari, Takao
Shimodaira, Kayoko
Nemoto, Tetsuo
Ohno, Hideaki
Kaneko, Yukihiro
Makimura, Koichi
Uchida, Katsuhisa
Miyazaki, Yoshitsugu
Yamaguchi, Hideyo
Shibuya, Kazutoshi
author_facet Okubo, Yoichiro
Tochigi, Naobumi
Wakayama, Megumi
Shinozaki, Minoru
Nakayama, Haruo
Ishiwatari, Takao
Shimodaira, Kayoko
Nemoto, Tetsuo
Ohno, Hideaki
Kaneko, Yukihiro
Makimura, Koichi
Uchida, Katsuhisa
Miyazaki, Yoshitsugu
Yamaguchi, Hideyo
Shibuya, Kazutoshi
author_sort Okubo, Yoichiro
collection PubMed
description Invasive fungal infections, particularly those considered opportunistic, have become a common and significant complication of procedures performed in advanced contemporary medicine. Among such infections, cryptococcosis, which is usually caused by infection with Cryptococcus neoformans and Cryptococcus gattii, is particularly problematic because this fungal infection occurs in immunocompromised and apparently immunocompetent individuals. It has been largely accepted that Cryptococcus species are recognized by cellular receptors and that Th1-type immune responses play an important role in defense mechanisms against the yeast. However, the interaction between the yeast and host tissue varies depending on the characteristics of the yeast and the immune status of the host. To gain a better understanding of the pathophysiology of cryptococcosis, we wish to emphasize the usefulness of histopathological examinations, because it allowed more detailed information of an extremely complex interaction between the causative yeasts and tissue response. In the present review, we describe the pathophysiology of cryptococcosis as largely revealed in our previous histopathological investigations of the experimental infection.
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spelling pubmed-37665972013-09-22 How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci Okubo, Yoichiro Tochigi, Naobumi Wakayama, Megumi Shinozaki, Minoru Nakayama, Haruo Ishiwatari, Takao Shimodaira, Kayoko Nemoto, Tetsuo Ohno, Hideaki Kaneko, Yukihiro Makimura, Koichi Uchida, Katsuhisa Miyazaki, Yoshitsugu Yamaguchi, Hideyo Shibuya, Kazutoshi Mediators Inflamm Review Article Invasive fungal infections, particularly those considered opportunistic, have become a common and significant complication of procedures performed in advanced contemporary medicine. Among such infections, cryptococcosis, which is usually caused by infection with Cryptococcus neoformans and Cryptococcus gattii, is particularly problematic because this fungal infection occurs in immunocompromised and apparently immunocompetent individuals. It has been largely accepted that Cryptococcus species are recognized by cellular receptors and that Th1-type immune responses play an important role in defense mechanisms against the yeast. However, the interaction between the yeast and host tissue varies depending on the characteristics of the yeast and the immune status of the host. To gain a better understanding of the pathophysiology of cryptococcosis, we wish to emphasize the usefulness of histopathological examinations, because it allowed more detailed information of an extremely complex interaction between the causative yeasts and tissue response. In the present review, we describe the pathophysiology of cryptococcosis as largely revealed in our previous histopathological investigations of the experimental infection. Hindawi Publishing Corporation 2013 2013-08-22 /pmc/articles/PMC3766597/ /pubmed/24058271 http://dx.doi.org/10.1155/2013/465319 Text en Copyright © 2013 Yoichiro Okubo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Okubo, Yoichiro
Tochigi, Naobumi
Wakayama, Megumi
Shinozaki, Minoru
Nakayama, Haruo
Ishiwatari, Takao
Shimodaira, Kayoko
Nemoto, Tetsuo
Ohno, Hideaki
Kaneko, Yukihiro
Makimura, Koichi
Uchida, Katsuhisa
Miyazaki, Yoshitsugu
Yamaguchi, Hideyo
Shibuya, Kazutoshi
How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title_full How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title_fullStr How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title_full_unstemmed How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title_short How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
title_sort how histopathology can contribute to an understanding of defense mechanisms against cryptococci
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766597/
https://www.ncbi.nlm.nih.gov/pubmed/24058271
http://dx.doi.org/10.1155/2013/465319
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