Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico

BACKGROUND: DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be inhibited by several compounds that act through different mechanisms, including clinically used drugs, such as the derivatives of...

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Detalles Bibliográficos
Autores principales: Tesauro, Cinzia, Morozzo della Rocca, Blasco, Ottaviani, Alessio, Coletta, Andrea, Zuccaro, Laura, Arnò, Barbara, D'Annessa, Ilda, Fiorani, Paola, Desideri, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766703/
https://www.ncbi.nlm.nih.gov/pubmed/24004603
http://dx.doi.org/10.1186/1476-4598-12-100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766703/
https://www.ncbi.nlm.nih.gov/pubmed/24004603
http://dx.doi.org/10.1186/1476-4598-12-100

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