Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer

Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association betw...

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Detalles Bibliográficos
Autores principales: Reese, Adam C., Hardin, Jill, Cheng, Iona, Casey, Graham, Witte, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766748/
https://www.ncbi.nlm.nih.gov/pubmed/24023525
http://dx.doi.org/10.3390/ph3103127
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author Reese, Adam C.
Hardin, Jill
Cheng, Iona
Casey, Graham
Witte, John S.
author_facet Reese, Adam C.
Hardin, Jill
Cheng, Iona
Casey, Graham
Witte, John S.
author_sort Reese, Adam C.
collection PubMed
description Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one’s genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk.
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spelling pubmed-37667482013-09-08 Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer Reese, Adam C. Hardin, Jill Cheng, Iona Casey, Graham Witte, John S. Pharmaceuticals (Basel) Article Increasing evidence suggests that prostatic inflammation plays a key role in the development of prostate cancer. It remains controversial whether non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of prostate cancer. Here, we investigate how a previously reported inverse association between NSAID use and the risk of aggressive prostate cancer is modulated by variants in several inflammatory genes. We found that NSAIDs may have differential effects on prostate cancer development, depending on one’s genetic makeup. Further study of these inflammatory pathways may clarify the mechanisms through which NSAIDs impact prostate cancer risk. MDPI 2010-10-08 /pmc/articles/PMC3766748/ /pubmed/24023525 http://dx.doi.org/10.3390/ph3103127 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Reese, Adam C.
Hardin, Jill
Cheng, Iona
Casey, Graham
Witte, John S.
Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title_full Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title_fullStr Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title_full_unstemmed Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title_short Non-Steroidal Anti-Inflammatory Drugs, Variation in Inflammatory Genes, and Aggressive Prostate Cancer
title_sort non-steroidal anti-inflammatory drugs, variation in inflammatory genes, and aggressive prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766748/
https://www.ncbi.nlm.nih.gov/pubmed/24023525
http://dx.doi.org/10.3390/ph3103127
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