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The determinants of propofol induction time in anesthesia
BACKGROUND: The required dose of anesthetics is generally smaller in patients with low cardiac output (CO). A high CO decreases the blood concentration of anesthetics during induction and maintenance of anesthesia. However, a high CO may also shorten the delivery time of anesthetics to the effect si...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Anesthesiologists
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766776/ https://www.ncbi.nlm.nih.gov/pubmed/24023993 http://dx.doi.org/10.4097/kjae.2013.65.2.121 |
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author | Adachi, Yushi U. Satomoto, Maiko Higuchi, Hideyuki Watanabe, Kazuhiko |
author_facet | Adachi, Yushi U. Satomoto, Maiko Higuchi, Hideyuki Watanabe, Kazuhiko |
author_sort | Adachi, Yushi U. |
collection | PubMed |
description | BACKGROUND: The required dose of anesthetics is generally smaller in patients with low cardiac output (CO). A high CO decreases the blood concentration of anesthetics during induction and maintenance of anesthesia. However, a high CO may also shorten the delivery time of anesthetics to the effect site, e.g. the brain. We assessed the time required for induction of anesthesia with propofol administered by target-controlled infusion (TCI), and investigated factors that modify the pharmacodynamics of propofol. METHODS: After measuring CO and blood volume (BV) by dye densitometry, propofol was infused using TCI to simulate a plasma concentration of 3 µg/ml. After infusion, the time taken to achieve bispectral index (BIS) values of 80 and 60 was determined. Age, sex, lean body mass (LBM), and cardiovascular parameters were analyzed as independent variables. The dependent variables were the time taken to achieve each BIS value and the plasma concentration of propofol (Cp) 10 min after the commencement of infusion. RESULTS: Multiple regression analysis revealed that a high CO significantly reduced the time taken to reach the first end point (P = 0.020, R(2) = 0.076). Age and LBM significantly prolonged the time taken to reach the second end point (P = 0.001). Cp was negatively correlated with BV (P = 0.020, R(2) = 0.073). CONCLUSIONS: Cardiac output was a statistically significant factor for predicting the time required for induction of anesthesia in the initial phase, whereas, age and LBM were significant variables in the late phase. The pharmacodynamics of propofol was intricately altered by CO, age, and LBM. |
format | Online Article Text |
id | pubmed-3766776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Anesthesiologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-37667762013-09-10 The determinants of propofol induction time in anesthesia Adachi, Yushi U. Satomoto, Maiko Higuchi, Hideyuki Watanabe, Kazuhiko Korean J Anesthesiol Clinical Research Article BACKGROUND: The required dose of anesthetics is generally smaller in patients with low cardiac output (CO). A high CO decreases the blood concentration of anesthetics during induction and maintenance of anesthesia. However, a high CO may also shorten the delivery time of anesthetics to the effect site, e.g. the brain. We assessed the time required for induction of anesthesia with propofol administered by target-controlled infusion (TCI), and investigated factors that modify the pharmacodynamics of propofol. METHODS: After measuring CO and blood volume (BV) by dye densitometry, propofol was infused using TCI to simulate a plasma concentration of 3 µg/ml. After infusion, the time taken to achieve bispectral index (BIS) values of 80 and 60 was determined. Age, sex, lean body mass (LBM), and cardiovascular parameters were analyzed as independent variables. The dependent variables were the time taken to achieve each BIS value and the plasma concentration of propofol (Cp) 10 min after the commencement of infusion. RESULTS: Multiple regression analysis revealed that a high CO significantly reduced the time taken to reach the first end point (P = 0.020, R(2) = 0.076). Age and LBM significantly prolonged the time taken to reach the second end point (P = 0.001). Cp was negatively correlated with BV (P = 0.020, R(2) = 0.073). CONCLUSIONS: Cardiac output was a statistically significant factor for predicting the time required for induction of anesthesia in the initial phase, whereas, age and LBM were significant variables in the late phase. The pharmacodynamics of propofol was intricately altered by CO, age, and LBM. The Korean Society of Anesthesiologists 2013-08 2013-08-27 /pmc/articles/PMC3766776/ /pubmed/24023993 http://dx.doi.org/10.4097/kjae.2013.65.2.121 Text en Copyright © the Korean Society of Anesthesiologists, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Research Article Adachi, Yushi U. Satomoto, Maiko Higuchi, Hideyuki Watanabe, Kazuhiko The determinants of propofol induction time in anesthesia |
title | The determinants of propofol induction time in anesthesia |
title_full | The determinants of propofol induction time in anesthesia |
title_fullStr | The determinants of propofol induction time in anesthesia |
title_full_unstemmed | The determinants of propofol induction time in anesthesia |
title_short | The determinants of propofol induction time in anesthesia |
title_sort | determinants of propofol induction time in anesthesia |
topic | Clinical Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766776/ https://www.ncbi.nlm.nih.gov/pubmed/24023993 http://dx.doi.org/10.4097/kjae.2013.65.2.121 |
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