Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233

Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in respo...

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Detalles Bibliográficos
Autores principales: Wu, Bin, Wu, Xiaodan, Sun, Min, Li, Minhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766860/
https://www.ncbi.nlm.nih.gov/pubmed/23917067
http://dx.doi.org/10.3390/md11082713
Descripción
Sumario:Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl(2). Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC(50) value of 14.8 µM and 22.3 µM.

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