Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233

Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in respo...

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Detalles Bibliográficos
Autores principales: Wu, Bin, Wu, Xiaodan, Sun, Min, Li, Minhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766860/
https://www.ncbi.nlm.nih.gov/pubmed/23917067
http://dx.doi.org/10.3390/md11082713
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author Wu, Bin
Wu, Xiaodan
Sun, Min
Li, Minhui
author_facet Wu, Bin
Wu, Xiaodan
Sun, Min
Li, Minhui
author_sort Wu, Bin
collection PubMed
description Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl(2). Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC(50) value of 14.8 µM and 22.3 µM.
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spelling pubmed-37668602013-09-09 Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233 Wu, Bin Wu, Xiaodan Sun, Min Li, Minhui Mar Drugs Article Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7βH-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11,14-tetraol (2), were produced as stress metabolites in the cultured mycelia of Pestalotiopsis sp. Z233 isolated from the algae Sargassum horneri in response to abiotic stress elicitation by CuCl(2). Their structures were established by spectroscopic means. New compounds 1 and 2 showed tyrosinase inhibitory activities with IC(50) value of 14.8 µM and 22.3 µM. MDPI 2013-08-02 /pmc/articles/PMC3766860/ /pubmed/23917067 http://dx.doi.org/10.3390/md11082713 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wu, Bin
Wu, Xiaodan
Sun, Min
Li, Minhui
Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title_full Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title_fullStr Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title_full_unstemmed Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title_short Two Novel Tyrosinase Inhibitory Sesquiterpenes Induced by CuCl(2) from a Marine-Derived Fungus Pestalotiopsis sp. Z233
title_sort two novel tyrosinase inhibitory sesquiterpenes induced by cucl(2) from a marine-derived fungus pestalotiopsis sp. z233
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766860/
https://www.ncbi.nlm.nih.gov/pubmed/23917067
http://dx.doi.org/10.3390/md11082713
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