Cargando…
Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean?
Cyanobacterial blooms are a major and growing problem for freshwater ecosystems worldwide that increasingly concerns public health, with an average of 60% of blooms known to be toxic. The most studied cyanobacterial toxins belong to a family of cyclic heptapeptide hepatotoxins, called microcystins....
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766863/ https://www.ncbi.nlm.nih.gov/pubmed/23921721 http://dx.doi.org/10.3390/md11082751 |
_version_ | 1782477334421438464 |
---|---|
author | Vareli, Katerina Jaeger, Walter Touka, Anastasia Frillingos, Stathis Briasoulis, Evangelos Sainis, Ioannis |
author_facet | Vareli, Katerina Jaeger, Walter Touka, Anastasia Frillingos, Stathis Briasoulis, Evangelos Sainis, Ioannis |
author_sort | Vareli, Katerina |
collection | PubMed |
description | Cyanobacterial blooms are a major and growing problem for freshwater ecosystems worldwide that increasingly concerns public health, with an average of 60% of blooms known to be toxic. The most studied cyanobacterial toxins belong to a family of cyclic heptapeptide hepatotoxins, called microcystins. The microcystins are stable hydrophilic cyclic heptapeptides with a potential to cause cell damage following cellular uptake via organic anion-transporting proteins (OATP). Their intracellular biologic effects presumably involve inhibition of catalytic subunits of protein phosphatases (PP1 and PP2A) and glutathione depletion. The microcystins produced by cyanobacteria pose a serious problem to human health, if they contaminate drinking water or food. These toxins are collectively responsible for human fatalities, as well as continued and widespread poisoning of wild and domestic animals. Although intoxications of aquatic organisms by microcystins have been widely documented for freshwater ecosystems, such poisonings in marine environments have only occasionally been reported. Moreover, these poisonings have been attributed to freshwater cyanobacterial species invading seas of lower salinity (e.g., the Baltic) or to the discharge of freshwater microcystins into the ocean. However, recent data suggest that microcystins are also being produced in the oceans by a number of cosmopolitan marine species, so that Hepatotoxic Seafood Poisoning (HSP) is increasingly recognized as a major health risk that follows consumption of contaminated seafood. |
format | Online Article Text |
id | pubmed-3766863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37668632013-09-09 Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? Vareli, Katerina Jaeger, Walter Touka, Anastasia Frillingos, Stathis Briasoulis, Evangelos Sainis, Ioannis Mar Drugs Article Cyanobacterial blooms are a major and growing problem for freshwater ecosystems worldwide that increasingly concerns public health, with an average of 60% of blooms known to be toxic. The most studied cyanobacterial toxins belong to a family of cyclic heptapeptide hepatotoxins, called microcystins. The microcystins are stable hydrophilic cyclic heptapeptides with a potential to cause cell damage following cellular uptake via organic anion-transporting proteins (OATP). Their intracellular biologic effects presumably involve inhibition of catalytic subunits of protein phosphatases (PP1 and PP2A) and glutathione depletion. The microcystins produced by cyanobacteria pose a serious problem to human health, if they contaminate drinking water or food. These toxins are collectively responsible for human fatalities, as well as continued and widespread poisoning of wild and domestic animals. Although intoxications of aquatic organisms by microcystins have been widely documented for freshwater ecosystems, such poisonings in marine environments have only occasionally been reported. Moreover, these poisonings have been attributed to freshwater cyanobacterial species invading seas of lower salinity (e.g., the Baltic) or to the discharge of freshwater microcystins into the ocean. However, recent data suggest that microcystins are also being produced in the oceans by a number of cosmopolitan marine species, so that Hepatotoxic Seafood Poisoning (HSP) is increasingly recognized as a major health risk that follows consumption of contaminated seafood. MDPI 2013-08-05 /pmc/articles/PMC3766863/ /pubmed/23921721 http://dx.doi.org/10.3390/md11082751 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Vareli, Katerina Jaeger, Walter Touka, Anastasia Frillingos, Stathis Briasoulis, Evangelos Sainis, Ioannis Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title | Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title_full | Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title_fullStr | Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title_full_unstemmed | Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title_short | Hepatotoxic Seafood Poisoning (HSP) Due to Microcystins: A Threat from the Ocean? |
title_sort | hepatotoxic seafood poisoning (hsp) due to microcystins: a threat from the ocean? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766863/ https://www.ncbi.nlm.nih.gov/pubmed/23921721 http://dx.doi.org/10.3390/md11082751 |
work_keys_str_mv | AT varelikaterina hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean AT jaegerwalter hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean AT toukaanastasia hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean AT frillingosstathis hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean AT briasoulisevangelos hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean AT sainisioannis hepatotoxicseafoodpoisoninghspduetomicrocystinsathreatfromtheocean |